Everything about Clock totally explained
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Circadian Locomotor Output Cycles Kaput, or
Clock is a gene which encodes proteins regulating
circadian rhythm. The CLOCK protein seems to affect both the persistence and length of the
circadian cycle. CLOCK forms part of a
basic-helix-loop-helix transcription factor.
BMAL-1 dimerizes with CLOCK
in vivo and transactivates gene expression of
Period and
Timeless in
drosophila by binding to
E-box elements in their promoters. BMAL1-CLOCK also regulates Cryptochrome genes (for example Cry1, Cry2) and Period genes (for example
Per1,
Per2,
Per3) in mammals. The BMAL-CLOCK complex itself is regulated by the expression of Per and Cry genes.
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